Tools to detect suspicious locking of resources

Hello all,

I was wondering what you use to find out what program/process has
locked a port/process/resource. For e.g. when you want to dismount a
thumbdrive, the OS says that the resource is busy and to try at a
later time. Or sometimes when you want to start a service, the OS
reports that the service is locked by another program. It takes me a
combination of netstat and Sysinternals to do that currently. Anyone
using a single tool to accomplish this instead?

Thanks,

JW